OK, this will be the best car-related scene in a movie thread. This will eventually result in a winner as voted for by you. You can post a link to a clip if you have one, but otherwise just describe the scene briefly and state from which movie it is. If anyone didn't see it yet, hopefully your description alone will make them go see it!
My personal favorite:
Mel Gibson & Danny Glover persuing the bad guys in what looks like a Pontiac Grand Prix on a motorway, crashing into a building, continuing the chase via the office-floor (ruining a few desks, chairs and copiers in the process), crashing back onto the motorway and eventually coming to an abrupt stop against a truck (which crushed the baddies and their car) sporting a sticker reading "If you can read this, you're too close".
Movie: Lethal Weapon 4.