Well, I found an auto yard in North Carolina which had a '69 Cadillac Fleetwood Limo. I was interested in the 3.21:1 rear axle ratio which was standard on the limos.
I contacted the place and bought it via credit card. The rear differential carrier which includes the ring and pinion I want. I made sure it was the correct gearing- it can be identified by the number stamped on the outside of the carrier. A "1" means 3.21 and a "2" means 2.94. The rear carrier weighs 90 lbs, incidentally.
Anyway, the car was ready today and I drove it home and was comparing this ratio with the former 2.94s.
As expected, I did notice a difference in hill climbing. I drove it up a steep hill in my neighborhood. With the tall 2.94 gears, it is best to leave it in 2nd gear; with the 3.21s I noticed it was revving more than necessary so I shifted into 3rd about halfway up the hill and it felt okay. No strain or anything; I was going about 40 mph.
I did one 40-60 mph test. Actually, it does it so quick it's kind of hard to both drive, watch the speedometer and time it. With the 2.94s, 40-60 was right around 4.0 seconds; with the 3.21s I got about 3.7 (which is what Car & Driver got with a '64 Sedan de Ville with 429-cu-in engine and 3.21 gears).
The weather was not ideal for acceleration tests... it was hot and I noticed a slight pinging at full throttle so backed off just a bit. Next time I will try it at night when it cools off more.
For those who are interested, here is an article about gear ratios. I is from way back (Motor Life, July, 1958) but what is written would apply to most American cars from the 1960s and '70s.